arachidonic acid (AA)

By Targets:	Apoptosis (1) COX (1) DYRK (1) Endogenous Metabolite (3) Lipoxygenase (3) MAGL (1) Phospholipase (2) Prostaglandin Receptor (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (5) Endocrinology (1) Inflammation/Immunology (5)

Targets Recommended: Amino Acid Derivatives Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-105872

Trifenagrel	Others	Cardiovascular Disease
Trifenagrel is a platelet aggregation inhibitor that inhibits the inducing effects of arachidonic acid (AA) and collagen. The ED₅₀s of trifenagrel for inhibiting AA- and collagen-induced platelet aggregation in guinea pigs were 1.4 mg/kg and 9.4 mg/kg, respectively .

HY-116246

5(S)-HETE lactone

Others Inflammation/Immunology

5(S)-HETE lactone is an arachidonic acid (AA) metabolite .
HY-119735

Curcolone

Others Cardiovascular Disease

Curcolone is a sesquiterpenoid that inhibits collagen-induced or arachidonic acid (AA)-induced platelet aggregation .

5(S)-HETE lactone	Others	Inflammation/Immunology
5(S)-HETE lactone is an arachidonic acid (AA) metabolite .

Curcolone	Others	Cardiovascular Disease
Curcolone is a sesquiterpenoid that inhibits collagen-induced or arachidonic acid (AA)-induced platelet aggregation .

HY-N12514

Cyclomulberrin	Others	Cardiovascular Disease
Cyclomulberrin is a extended flavonoid that shows inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation, with IC₅₀ value of 128.2 μM .

HY-113445

Thromboxane B3	COX Endogenous Metabolite	Endocrinology
Thromboxane B3 is a prostaglandin analog derived from arachidonic acid (AA) in the cyclooxygenase (COX) metabolic pathway. Thromboxane B3 is generated from arachidonic acid (AA) in platelets and vascular endothelial cells through the catalysis of cyclooxygenase (COX) and thromboxane synthase (TXS). Thromboxane B3 has been reported to be formed by human platelets upon ingestion of eicosapentaenoic acid (C20: 5ω3) .

HY-136500

Prostaglandin H2 PGH2	Endogenous Metabolite	Cardiovascular Disease
Prostaglandin H2 (PGH2), a potent vasoconstrictor, is produced by the conversion of Arachidonic acid (AA). Prostaglandin H2 is asubstrate for the production of Prostaglandins (PGs) and thromboxanes (TXs) .

HY-106200

CJ-13,610	Lipoxygenase	Inflammation/Immunology
CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC₅₀ of about 70 nM . PMNL: polymorphonuclear leukocytes; AA: arachidonic acid

HY-105120A

Vapiprost hydrochloride	Prostaglandin Receptor	Others
Vapiprost hydrochloride is a thromboxane A2 receptor antagonist. Vapiprost inhibits the aggregation and ATP release stimulated with U-46619, collagen or arachidonic acid (AA) at an IC₅₀ of less than 2.1×10 ^-8 M .

HY-W013214

Ethyl arachidonate	Endogenous Metabolite	Others
Ethyl arachidonate is a lipophilic esterified form of arachidonic acid (AA) and can be added into dietary regimens or fed to cultured cells as a source of exogenous arachidonate. Ethyl arachidonate is the main species of fatty acid ethyl esters (FAEE) in brain of alcohol-intoxicated subjects .

HY-P3029

Phospholipase A2 PLA2	Phospholipase	Others
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

HY-143791

ALOX15-IN-2	Lipoxygenase	Inflammation/Immunology
ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with _IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively .

HY-143787

ALOX15-IN-1	Lipoxygenase	Inflammation/Immunology
ALOX15-IN-1 (compound 8b) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with _IC50s of 0.04 and 2.06 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively .

HY-N2892

Aristolactam A IIIa Aristololactam A IIIa; Sch 546909	DYRK	Cardiovascular Disease Cancer
Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells .

HY-134556

2'-Hydroxyflavanone	Apoptosis	Inflammation/Immunology Cancer
2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC₅₀s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP) .

HY-137119

(±)5-iPF2α-VI 5-iso Prostaglandin F2α-VI	Others	Others
(±)5-iPF2α-VI (5-iso Prostaglandin F2α-VI) is the racemate of 5-iPF2α-VI. 5-iPF2α-VI is a regioisomeric isoprostane formed from arachidonic acid (AA) and is a biomarker of oxidative stress .

HY-116141

7-Hydroxycoumarinyl arachidonate 7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate	Phospholipase MAGL	Others
7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer .

Cat. No.	Product Name	Type

HY-P3029

Phospholipase A2 PLA2	Biochemical Assay Reagents
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

Cat. No.	Product Name	Target	Research Area

HY-P3029

Phospholipase A2 PLA2	Phospholipase	Others
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2 is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013214

Ethyl arachidonate	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Ethyl arachidonate is a lipophilic esterified form of arachidonic acid (AA) and can be added into dietary regimens or fed to cultured cells as a source of exogenous arachidonate. Ethyl arachidonate is the main species of fatty acid ethyl esters (FAEE) in brain of alcohol-intoxicated subjects .

HY-N12514

Cyclomulberrin	Structural Classification Flavonoids Source classification Plants Moraceae Other Flavonoids Morus alba Linn.	Others
Cyclomulberrin is a extended flavonoid that shows inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation, with IC₅₀ value of 128.2 μM .

HY-N2892

Aristolactam A IIIa Aristololactam A IIIa; Sch 546909	Structural Classification Antibiotics Fissistigma balansae (A. DC.) Merr. Source classification Disease Research Plants Annonaceae Anticancer Other Antibiotics	DYRK
Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells .

HY-134556

2'-Hydroxyflavanone	Structural Classification Flavonoids Mimosa pudica Linn. Leguminosae Flavonones Source classification Plants	Apoptosis
2'-Hydroxyflavanone is a flavanone that can inhibit cancer cell proliferation, induce apoptosis, and reduce inflammation. 2'-Hydroxyflavanone shows inhibitory effect on platelet aggregation caused by two inducers with IC₅₀s 47.8 μM arachidonic acid (AA) and 147.2 μM aenosine diphosphate (ADP) .

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arachidonic acid (AA)

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